Enhanced phagocytic capacity endows chondrogenic progenitor cells with a novel scavenger function within injured cartilage

Enhanced phagocytic capacity endows chondrogenic progenitor cells with a novel scavenger function within injured cartilage.

OBJECTIVE Articular cartilage harbors chondrogenic progenitor cells (CPCs), a population that responds chemotactically to cell death. Because this behavior is reminiscent of macrophages, we hypothesized that CPCs have macrophage-like capabilities for scavenging cell and tissue debris through phagocytosis. DESIGN CPCs, chondrocytes, synoviocytes, and macrophages were cultured with fluorophore-...

The Identification of CD163 Expressing Phagocytic Chondrocytes in Joint Cartilage and Its Novel Scavenger Role in Cartilage Degradation

BACKGROUND Cartilage degradation is a typical characteristic of arthritis. This study examined whether there was a subset of phagocytic chondrocytes that expressed the specific macrophage marker, CD163, and investigated their role in cartilage degradation. METHODS Cartilage from the knee and temporomandibular joints of Sprague-Dawley rats was harvested. Cartilage degradation was experimentall...

Enhanced chondrogenic differentiation of induced pluripotent stem cells derived from human articular cartilage

INTRODUCTION: Acute impact-induced joint trauma often affects young and middleaged adults and significantly increases the risk of developing posttraumatic osteoarthritis. Since joint replacement surgery is not a realistic option for young individuals, there is a need for the development of alternative therapies to treat large cartilage defects. Because of their unlimited self-renewal, developme...

Cartilage Protective and Chondrogenic Capacity of WIN-34B, a New Herbal Agent, in the Collagenase-Induced Osteoarthritis Rabbit Model and in Progenitor Cells from Subchondral Bone

We sought to determine the cartilage repair capacity of WIN-34B in the collagenase-induced osteoarthritis rabbit model and in progenitor cells from subchondral bone. The cartilage protective effect of WIN-34B was measured by clinical and histological scores, cartilage area, and proteoglycan and collagen contents in the collagenase-induced osteoarthritis rabbit model. The efficacy of chondrogeni...

Tumor-Bearing Mice Capacity To Prime Anti-Tumor Responses in Merocytic Dendritic Cells with Enhanced Prolonged Antigen Storage Endows